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Cells were pre-plated for 1 h to enrich cardiomyocytes, seeded on laminin-coated dishes, and maintained in DMEM/F12 supplemented with 10% foetal bovine serum (FBS) and 1% penicillin/streptomycin

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Animals Swiss Webster male mice were purchased from Charles River Laboratories (Wilmington, MA, US)

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Evening dosing (30 to 60 minutes before sleep) is strongly recommended so that nausea and flushing peak during sleep rather than during the day

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A review of microbiota and irritable bowel syndrome: future in therapiesm

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