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Unfortunately, decreasing muscle in individuals with obesity may have profoundly negative metabolic consequences and exacerbate many obesity-related health conditions 5

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Treatment with the soluble TNF- receptor etanercept or the JAK inhibitor tofacitinib reversed CRPS IgGinduced hyperalgesia and microglial activation were reversed ( in vitro , identifying a moderate correlation between NPP and ATP-induced upregulation of TNF- expression ( Mechanistically, PICs can directly enhance central sensitization by increasing excitatory synaptic transmission or suppressing inhibitory synaptic transmission