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doi:10.1159/000450702 96. Pinheiro, J., Bates, D., DebRoy, S., Sarkar, D., Heisterkamp, S., Willigen, B., & Ranke, J

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The response to acute focal TBI with tissue damage develops in the following phases: (i) cell death and inflammation, (ii) cell proliferation, tissue replacement with fibrotic scar and wound closure and (iii) tissue remodelling and neuroplasticity aimed at restoration and functional compensation 26,160 (Fig