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In the semaglutide group, there was an improvement in quality of life according to the Kansas City Cardiomyopathy Questionnaire (KCCQ-CSS), with a mean change in KCCQ-CSS score of 13.7 points with semaglutide and 6.4 points with placebo (p 1% significantly decreased hospitalisations (aOR 1.33

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Biomed Pharmacother 163:114833

Tesamorelin acts through GHRH receptor signaling, while ipamorelin targets ghrelin (GHS-R1a) pathways, supporting complementary stimulation of pulsatile GH release