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Of 22 glycolytic enzymes, we found that xCT expression was most strongly correlated with dependency on the glucose transporter GLUT1 ( SLC2A1 ) in GBM and also strongly correlated with dependency on GLUT1 in sarcoma cell lines (i.e., high xCT expressing cells have large negative CERES scores, indicating greater dependency on GLUT1) (Fig

Genomics 49 , 496504 (2017)