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FDA therefore identified a theoretical carcinogenic concern where chronic exposure activates telomerase or extends telomeres in cells capable of malignant transformation

This maintenance dose continues for the remainder of the active cycle and carries forward into future cycles

Alex J Med

61 SchnekenburgerM.MorceauF.DuvoixA.DelhalleS.TrentesauxC.DicatoM.et al (2003)

Activated macrophages (M1 type macrophages) invade the synovium, and the imbalanced ratio of M1 type and anti-inflammatory macrophages (M2 type) in synovial tissues as well as the differentiation of macrophage precursor cells into osteoclasts are important characteristics of RA (203)