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If AD has an infectious etiology, this may explain the decreased serum A 142 : A 140 ratios evident in AD patients, as the antimicrobial forms of A would be preferentially aggregated in the brain (and therefore not enter the serum) as part of an immune response to the detriment of synaptic regulation and neuronal survival (Soscia et al., 2010

Torii S, Shintoku R, Kubota C, Yaegashi M, Torii R, Sasaki M, et al