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One of the earliest biochemical changes seen in PD is a decrease in the levels of total GSH which occurs even before a reduction in mitochondrial complex 1 activity, dopamine levels, or the neurodegeneration that are all associated with the disease (Chinta et al., 2007)

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However, when combined with simvastatin, the required metformin dosage is reduced by at least half, while simultaneously enhancing its inhibitory effects on glioma cell proliferation

Without adjusting doses, patients may experience lows