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Lipid profile improvements (TRIUMPH-4): Non-HDL cholesterol: Clinically meaningful reduction Triglycerides: Significant reduction hsCRP (inflammatory marker): Significant reduction HDL cholesterol: Not significantly improved (consistent with Phase 2 findings) The triglyceride reduction is particularly notable and likely related to glucagon receptor activation, which enhances fat oxidation

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In conclusion, as GLP-1RA glucose-lowering drugs have been increasingly used in clinical practice, their cardiovascular benefits have also been identified