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Nevertheless, concerns about Ag NP toxicity persist, and some studies suggest potential neuronal cell survival and synaptic activity impairment, highlighting the need of more research on surface functionalization and targeted delivery strategies to mitigate these risks

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Current clinical treatment guidelines aim for a functional cure for CHB, which involves sustained negativity for hepatitis B surface antigen (HBsAg), undetectable HBV DNA, normal liver biochemical indicators, and improvement of liver tissue lesions after treatment cessation