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Risk of pancreatitis with GLP-1 receptor agonists: A systematic review

Contraindications and precautions include: Personal or family history of medullary thyroid carcinoma (contraindicated) Multiple endocrine neoplasia syndrome type 2 (MEN 2) (contraindicated) Pregnancy or planning pregnancy (not recommended) Breastfeeding (not recommended) History of severe hypersensitivity to tirzepatide or excipients History of pancreatitis (requires careful assessment) Gallbladder disease or risk factors Severe gastrointestinal disease Diabetic retinopathy (requires monitoring if present) Suicidal thoughts or behaviors (monitor for depression/suicidal ideation) Patients should be advised about reduced oral contraceptive effectiveness and the need for alternative or backup contraception for 4 weeks after initiation and each dose increase

In this study, researchers aimed to increase the levels of this important anti-oxidant (GSH) by supplementation with whey-based protein in 24 CF patients for a period of 3 months

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Oncol Lett (2021) 22(5):767