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Vascular disease resulting in poor perfusion is a common sequel of diabetes, obesity, and atherosclerosis

Omega-3 fatty acids, particularly DHA (docosahexaenoic acid) and EPA (eicosapentaenoic acid), are well-known for their heart health benefits

The core mechanism lies in mimicking the naturally existing GHK-Cu complex in the human body, which can directly interact with cell DNA and regulate the expression of genes related to tissue repair, anti-inflammatory and antioxidant functions

While the study establishes a compelling systemic role for SLC25A45 in fuel switching, important questions remain regarding the tissue-specific contributions of this pathway and how carnitine biosynthesis and utilization are differentially regulated across dietary, disease, and sexually dimorphic contexts

[DOI] [PMC free article] [PubMed] [Google Scholar] 43.Di Domenico E.G., Farulla I., Prignano G., Gallo M.T., Vespaziani M., Cavallo I., Sperduti I., Pontone M., Bordignon V., Cilli L