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The GLP-1 receptor agonist liraglutide was able to reduce Bax expression in pancreatic cells from T2DM rats, and Bcl-2 expression was increased, islet tissue structure was improved, insulin-positive expression was increased, and -cell apoptosis was reduced (Liu et al., 2021)

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Once-weekly semaglutide administered after laparoscopic sleeve gastrectomy: effects on body weight, glycemic control, and measured nutritional metrics in Japanese patients having both obesity and type 2 diabetes