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However, the drug's significant physiological effectsparticularly the potential for severe urine dilution from increased water intakecan create conditions where a false negative is more likely to occur

Circ Res 2006;98:596-605.PubMed 117

Clinical outcomes following termination of immunotherapy due to long-term benefit in MSI-H colorectal cancer

2013 Feb 5

While there are legitimate international API suppliers that are registered with the FDA, overseas sourcing adds complexity and risk to the supply chain