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Serious side effects were rare but longer studies are required to fully understand long term risks

However, some studies indicate an increased risk of fractures, possibly due to weight loss-associated reductions in bone mineral density (BMD)

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10.1007/s00198-018-4649-8 Summary Keywords glucagon-like peptide-1, diabetes mellitus, glucagon-like peptide 1 receptor agonists, osteoporosis, bone resorption Citation Xie B, Chen S, Xu Y, Han W, Hu R, Chen M, Zhang Y and Ding S (2021) The Impact of Glucagon-Like Peptide 1 Receptor Agonists on Bone Metabolism and Its Possible Mechanisms in Osteoporosis Treatment