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doi: 10.3389/fendo.2025.1619462 74 NigiLGriecoGEVentrigliaGBruscoNMancarellaFFormichiCet al

Demographics, prescribing practices, and procedure outcomes were captured

Cycling Protocols Standard cycling involves 4-8 weeks of daily use followed by an equal off period before resuming if needed

others prefer a light meal Anti-nausea options: ondansetron (Zofran) 4 mg 30 minutes before, or ginger supplements Gradual dose increases community protocols describe adding 50-100 mcg every 2-3 days per the titration protocol Facial Flushing Prevalence: 60-70% of users Onset: 15-60 minutes Duration: 1-3 hours Caused by MC1R-mediated vasodilation