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The insulin-independent effects on glycogen synthesis are mediated through GLP-1 signaling through phosphoinositide 3-kinase (PI3K), AKT, PKC, and protein phosphatase-1 (PP-1) activity, but the interplay between these enzymes is not currently fully understood in GLP-1-mediated glycogen metabolism [88]

In the end, 92 subjects were randomly assigned

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The studys primary endpoint was change in the cerebral glucose metabolic rate in the cortical regions of the brain (hippocampus, medial temporal lobe and posterior cingulate), which was not met