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These frameworks could also support the integration of experimental outputs with computational models and digital twin platforms, enabling advanced data analytics, cross-laboratory reproducibility, and multi-scale modeling of physiological processes

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Dihydrofolate Reductase (DHFR): Three variants affect folate dynamics: 19 bp Intron Deletion: Homozygotes show disrupted tissue folate stores and a twofold increase in risk of spina bifida in offspring