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PMID: 19931318.

When looking at visual acuity with the Snellen eye test, those in the supplement group saw a 9% improvement after 6 months (0.55 to 0.60) compared to a 3.7% decrease in the placebo group (0.55 to 0.53)

Low folate levels are found in up to 38% of patients with depression , and supplementation has been shown to enhance the effectiveness of antidepressants, with one study reporting a 93.3% improvement rate

Botch is a -glutamyl cyclotransferase that deglycinates and antagonizes Notch