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This process can upregulate the expression of steroidogenic genes such as those encoding aromatase and StAR, along with the LHR gene (105, 106)

Bhardwaj and Chalasani, 2007

By downregulating CHAC1 expression, DJ-1 helps maintain higher intracellular levels of GSH, thus enhancing the cells antioxidant capacity and protecting neurons from oxidative damage

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Because eltrombopag has few side effects in children, the pediatric hematology community has already started using this drug to intervene earlier than one year from diagnosis