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Although GLP-1RAs are generally well tolerated and considered safe drugs, as they gain widespread use for obesity, rare but serious adverse effects such as gastroparesis, bowel obstruction, pancreatitis and non-arteritic anterior ischemic optic neuropathy are emerging

Even 2x per week makes significant difference

Owing to these actions, the principal sites of POMC expression and its processing into biologically active -MSH lie within the central nervous system (hypothalamus and pituitary gland) and in the skin, but there is some evidence demonstrating that -MSH is also produced in other peripheral tissues (Smith and Funder, 1988)

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The profile of the REVEAL-1 Cohort closely mirrors that of the REMAIN-1 Midpoint and Pivotal Cohorts, with an average age of 50 and a gender distribution of 86% women