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Additionally, upregulated Notch binding and metallopeptidase activities matched expression changes of TN-R (Notch-regulated ECM protein) and CTSS, potentially aggravating blood-brain barrier disruption via Notch-dependent microglial activation [67, 68] (Fig

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Spectra were simulated with MATLAB R2021a using the EasySpin 5.2.33 package

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In December 2022, the FDA expanded the label to include adolescents aged 12 to 17 with a BMI at or above the 95th percentile for age and sex, based on results from the STEP TEENS trial [2]