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Using preclinical models, a causal link between GSH levels in the nucleus accumbens and performance was established, showing that both local and systemic modulation of GSH can influence motivated performance and stamina (17)

Further, collaborative research involving multi-omics approaches (genomics, metabolomics, and microbiomics) could provide insights into individual variability and enhance the predictive power of preclinical findings

Heritable variants in different urate transporters also affect serum urate responses to dietary challenges such as fructose and potentially some medications, but with mixed results for diuretics

doi: 10.1016/0026-0495(81)90052-4 61 FazeliPKLawsonEAPrabhakaranRMillerKKDonohoDAClemmonsDRet al

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