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In clinical trials, tirzepatide achieved up to 18% weight loss compared to semaglutide at 12%

Clin Biochem 20:17 Schuck PF, da Costa Ferreira G, Tahara EB, Klamt F, Kowaltowski AJ, Wajner M (2010) cis-4-decenoic acid provokes mitochondrial bioenergetic dysfunction in rat brain

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This helps prevent dangerous interactions