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This is due to the models ability to resemble more closely the organotypic histomorphology and microenvironment of hepatocytes in the liver in vivo (Lv et al., 2017), the impact of metabolic cooperation between different cell types on metabolic profiling and long-term survival being metabolically competent

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[DOI] [PubMed] [Google Scholar] 131.Alexiadou K, Hartley A, Tan TMM et al

As for CASP3, studies have shown a correlation between abnormal expression and BRCA patient prognosis, and an abnormal CASP3-mediated apoptosis pathway is a potential mechanism of chemoresistance in BRCA 40,41