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SIRT2 deacetylates Smad2 and promotes its ubiquitination at K451, deacetylates Smad3 at K341 and K378, and reduces the phosphorylation, acetylation, and nuclear translocation of Smad2 and Smad3 in the kidneys of UUO mice to inhibit the activation of Smad2 and Smad3, ultimately mitigating kidney injury in the UUO mice model (Yang et al., 2023)

Many involved small sample sizes and short follow-up periods

SGLT2 inhibitors were used as the comparator because this drug has no known as- sociation with suicide death and was used in similar clinical situations (predominantly as second-line or third-line glucose- lowering drugs for treatment of type 2 diabetes) during the study period, with both GLP-1 receptor agonists and SGLT2 inhibitors being recommended for patients with type 2 diabetes and high cardiovascular risk

Consistent with this finding, GLP-1R V229A also presented with significantly increased levels of receptors segregated to lipid rafts (35) prior to exendin-4 stimulation versus GLP-1R WT (Figure 5B)