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Its potency varies depending on the brand, dosage, and individual response

There is also a growing concern about unapproved, compounded versions of semaglutide, which are often sold online during shortages of the official brand-name products

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They stimulate insulin secretion when blood sugar is elevated, slow gastric emptying, and reduce appetite, leading to improved glycaemic control and often significant weight loss

Quick answer: All three now operate under the 2025 rule that compounded GLP-1s require the personalized-dosing route, but their pricing and models differ