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Through integrated multi-omics approaches and rigorous mechanistic studies, we demonstrated how PRMT1-mediated post-translational modifications orchestrate a cascade of molecular events leading to TEC injury

While this chemotherapy regimen demonstrates favorable response rates in most patients, the emergence of drug resistance remains a primary challenge (8)

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This wide therapeutic window provides reassurance about acute safety

The main mechanism responsible for the longevity-promoting effects of spermidine is the stimulation of autophagy (227)