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Anemia can lead to tiredness, dizziness, paleness (especially pale extremities such as fingers and toes) and increased heart rate

The honest answer is that the human safety data is limited compared to decades-old pharmaceuticals, but the preclinical safety record across multiple species is unusually clean for a peptide with this level of biological activity

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Borisy that MAP1 and MAP2, which form the projections from cytoplasmic microtubules, are rapidly degraded by trypsin, with tubulin being little affected under the conditions employed (Vallee and Borisy, 1977)