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The orexigenic action of ghrelin is mediated through direct stimulation of the orexigenic AgRP/NPY neurons and concomitant inhibition of the anorectic POMC/CART neurons in the ARC (143, 144)

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doi: 10.1016/j.cell.2012.03.042 4 TangDKangRBergheTVVandenabeelePKroemerG

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