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[DOI] [PubMed] [Google Scholar] 19.Hossain A., Yamaguchi F., Hirose K., Matsunaga T., Sui L., Hirata Y., Noguchi C., Katagi A., Kamitori K., Dong Y., et al

Side-by-Side Comparison Parameter Receptors Cagrilintide AMY1R/2R/3R + CTR Semaglutide GLP-1R Tirzepatide GLP-1R + GIPR Retatrutide GLP-1R + GIPR + Glucagon-R Parameter Half-life Cagrilintide ~7-8 days Semaglutide ~7 days Tirzepatide ~5 days Retatrutide ~6 days Parameter Dosing frequency Cagrilintide Once weekly Semaglutide Once weekly Tirzepatide Once weekly Retatrutide Once weekly Parameter Max studied dose Cagrilintide 4.5 mg/week (mono) Semaglutide 2.4 mg/week Tirzepatide 15 mg/week Retatrutide 12 mg/week Parameter Peak monotherapy weight loss Cagrilintide 11.8% at 68 wk Semaglutide 14.9-17% at 68 wk Tirzepatide 22.5% at 72 wk Retatrutide ~24% at 48 wk Parameter FDA status (June 2026) Cagrilintide Investigational Semaglutide Approved (2021) Tirzepatide Approved (2023) Retatrutide Investigational Parameter HbA1c reduction (T2D) Cagrilintide ~0.9 pp mono

Dimensions: 8256 x 5504 px | 69.9 x 46.6 cm | 27.5 x 18.3 inches | 300dpi Date taken: 4 May 2022 Location: Naples, Florida, United States of America Available for Editorial use only

Supplement Facts: Serving Size: 1/2 tablet Servings Per Container: 200 Amount Per Serving: Vitamin D3 (cholecalciferol): 50 g (2000 IU) (1000% RI) Vitamin K2 (menaquinone-7): 50 g (67% RI) Protein: 0 g Carbohydrate: 0 g of which sugars: 0 g Fat: 0 g of which saturates: 0 g Fibre: 0 g Salt: 0 g *RI - Reference Intake Ingredients: Bulking agents: microcrystalline cellulose, calcium phosphate, starch

The proportions of patients experiencing treatment-related adverse events in the three treatment groups (20 mg, 40 mg, and placebo groups) were similar at 86.5%, 88.0%, and 85.3% respectively