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It has been postulated that the restoration of insulin signaling sensitivity by GLP-1RA treatment and improved growth factor signaling, as shown by increased levels of activated ERK1 and insulin receptor substrate-1 (IRS1) following semaglutide treatment, is responsible for the normalization of stem cell proliferation and neurogenesis in the brain [93]

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J Lipid Res 56(3):489501

In fact for some people, the lower dose is still going to be highly effective in terms of 0.25mg and there may not be a need to increase the dose even though the clinical trials suggested that was what needed to happen.We do not know what the actual effect of 0.25mg is

I think we had all been expecting less, given that the launch of Novos previous obesity drug, Saxenda, wasnt very successfulalbeit with about 5% weight loss. However, investors have now definitely taken note, changing the landscape of pharma stocks