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Three main paths exist: Weeks 37-48 Summary: Completion and Planning Weight loss: 3-7 pounds this period (49-53 pounds total, ~24% of starting weight average) Weekly loss rate: 0.25-0.6 pounds weekly (minimal but still progressing) Final results: 24.2% average total body weight loss by week 48 Discontinuation rate: 1-2% during this period Overall completion rate: 74% of people who started week 1 completed week 48 Psychological state: Proud of achievement, planning next steps What Actually Determines Your Timeline Results Individual timelines vary from the averages presented

Pharmacol Biochem Behav 108:28-43

Following 3 h of drug treatments, 5 M of the cell-permeable, ROS-sensitive dye CellROX Deep Red (Invitrogen, Stockholm, Sweden) was added to each sample and incubated at 37 C for 30 min

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Data collection The study was conducted at the Cannabis Research Laboratory (NYSPI, Columbia University Irving Medical Center) and supervised by the CRO ClinSmart, which provided data management, eCRF preparation, data monitoring and safety management