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In the United States, febuxostat is tolerated at doses of 40 and 80 mg per day, while in Europe it is 120 mg per day, and in Japan it is 1060 mg per day

The result, supported by the synergistic pathway analysis of Norman et al

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4-Hydroxyestrogens are endogenous neuroestrogens that can strongly protect neurons against oxidative death by promoting p53 cytoplasmic localization

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