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After coronary artery ligation in mice, intraperitoneal T4 treatment upregulated cardiac ILK and Akt activity, enhanced early myocyte survival, and improved cardiac function establishing the mechanistic basis for the cardiac and broader tissue-repair claims associated with thymosin beta-4 and its 1723 fragment TB-500

41 Further studies also demonstrated that MLCK activation triggers caveolin-1-dependent endocytosis of occludin to effect structural and functional TJ regulation

I., Acosta, A., Faubion, S., Shufelt, C., & Hurtado Andrade, M

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Marine Environmental Research