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Human evidence - Phase 2 NEJM (Jastreboff et al., 2023) 338 adults with obesity but no diabetes

Aging and B12 Deficiency Vitamin B12 deficiency can be caused by a number of factors, including a vegetarian diet, weight loss surgery, celiac disease and Crohns disease

Primary handling editor: Benjamin Bessieres

Rhubarb is native to cool, temperate, and subtropical areas in Mongolia, India, and China

Another was the discovery that tight junctional permeability is dynamic, altered by systemic inflammation and other factors such as enterotoxins and the volume of fluid absorption [23, 39], initially reported in the early 1980s in clinical studies of intestinal permeability in arthritis and celiac disease patients [37, 40]