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Finally, the role of ferroptosis in renal fibrosis resolution is entirely unexplored: it is unclear whether activating or inhibiting ferroptosis could promote fibrosis regression in advanced CKD, a critical question for reversing established disease

Ischemia triggers redox reaction between PUFAs and phospholipids in cardiomyocytes, which results in powerful oxidative damage during the reperfusion stage [106]

The mechanism story is broad, but most of it is built on cell and animal models

Inhibiting vascular smooth muscle cell proliferation mediated by osteopontin via regulating gut microbial lipopolysaccharide: a novel mechanism for paeonol in atherosclerosis treatment