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This acute response generates vast amounts of reactive oxygen species (ROS) designed to destroy the invading pathogens

Periodontitis and CKD share several common risk factors, including obesity, smoking, and advanced age, with accumulating evidence supporting an association between the two conditions (127, 128)

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To our knowledge, the innervation in the intestinal mucosa, including the ileum and colon, is predominantly vagal afferents, with minimal motor neurons present 66,67