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Our objectives were to compare incretin concentrations and rates of glucose production and gluconeogenesis in youth with type 2 diabetes before and after short-term metformin therapy compared with peers with normal glucose tolerance (NGT)

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112 Like other gastrointestinal peptides, GLP-1 is also produced in the CNS, 113 particularly the nucleus of the solitary tract (NTS) and hypothalamus, with high levels of GLP-1 receptor mRNA present in ARC and PVN

"People with diabetes and obesity have elevated rates of depression, anxiety, and suicide," Mark Taylor, MBBS, study co-author and psychiatrist from Griffith University, tells SELF

By maintaining NAD + levels, NAPRT helps protect cells from oxidative stress, which is linked to aging and various diseases 225,226