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It is well known that after proinsulin is packaged into vesicles in the Golgi apparatus (beta-granules) of pancreatic cells of Langherans islets (42), the C-peptide is removed, leaving the A-chain and B-chain bound together by disulfide bonds, thus constituting the insulin molecule

Similarly, both the pill and the birth control shot have been linked to lower levels of vitamin B12, although, its not yet known whether this leads to any symptoms or need for treatment since the levels were still within the range thats accepted as normal [27]

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