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M., Larson, M

Testing may include SAM, SAH, methionine, homocysteine, whole-blood histamine, copper, zinc, ceruloplasmin, urinary pyrroles, organic acids, lactate, pyruvate, glutathione-related markers, 8-OHdG and lipid peroxides when clinically appropriate

The significant increase in fissures observed in the PCPA-induced insomnia model group suggests that sleep disturbances may lead to notable changes in brain tissue morphology (Figures 8A,B)