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Clinical trials of brand-name semaglutide showed an average of 15% weight loss plus reduced cardiovascular risk in patients with metabolic syndrome these studies inform how the active ingredient is understood, but the safety, efficacy, and quality data from those trials do not directly apply to compounded preparations

Collectively, these analyses suggest that the composition of the gut microbiota may only modestly influence circulating levels of TMAO in patients with T2D, and in subjects with IHD or T2D abundance of the CAG01909 taxon is not linked with serum TMAO