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Key communication points Cardiovascular outcomes trials have inherent differences in design, duration, and study cohorts, which prevents direct comparisons between the agents regarding reports of MACE

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Scientific Reports DOI:10.1038/s41598-026-60835-w Abstract Enhanced HGF with increased receptor affinity and nitration-dysfunction resistance through interaction with lipoic acid trisulfide Myogenic stem cell activator HGF (hepatocyte growth factor) undergoes nitration of tyrosine residues (Y198, Y250) predominantly on fast-twitch fibers to lose its binding affinity to the signaling receptor c-met, in response to peroxynitrite (ONOO ) generation during aging