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Of note, C1-27 inhibited the clonogenic survival of HCT116 cells at sub-micromolar concentrations (Fig

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PT-141 does not interact significantly with cytochrome P450 enzymes, minimizing potential for drug-drug interactions compared to oral medications metabolized through hepatic pathways

As controls for the synergistic combination of ceftazidime/avibactam (AVI/CAZ), each component was also used at the lower concentration present in the combination as well as higher concentrations that individually inhibited 2030% of growth