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Chin J New Drugs Clin Remedies

Common clinical indications include rotator cuff-related inflammation, adhesive capsulitis, glenohumeral osteoarthritis, and synovitis

Biguanide-derived neuroprotective agent (metformin) To mitigate neuroinflammation and mitochondrial dysfunction in PD, metformin was encapsulated into PLGA, which were further coated with BV2 microglial cell membranes to enhance the targeting efficiency to neuroinflammatory sites (BV2-metformin-loaded PLGA) for intranasal administration 19

Additionally, due to budgetary constraints, certain crucial assessments such as plasma carnitine levels and a wider array of inflammatory and cytokine biomarkers, and even serum lactate could not be carried out, which could have provided valuable insights

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