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According to the FDA prescribing information for Zepbound, the most common gastrointestinal adverse reactions in the SURMOUNT clinical trials included nausea (24-30%), diarrhea (18-24%), vomiting (8-12%), constipation (16-17%), dyspepsia (5-9%), and abdominal pain (6-10%), with rates varying by dose

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The $50 copay will not count toward the Part D deductible, nor does it count toward the $2,100 annual out-of-pocket cap on prescription drug costs

Nonetheless, the underlying reasons for the inconsistencies in the reported associations between T2DM and levels of plasma DPP-4 activity (lower, unaltered, higher) have not been adequately explained, although one study did suggest that it might be related to the populations studied, with changes only becoming evident once moderate or severe hyperglycaemia becomes established (68)

So, maintaining adequate levels of glutathione is incredibly important