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These results (31, 276) suggest that hucMSC-exosomes suppressed M1 macrophages, which produce IL-1.IBD mices weight loss, shorter colon, compromised structural integrity of colonic tissues, elevated pyroptosis-related proteins (NLRP3, GSDMD-N, and caspase-1), and proinflammatory cytokines (IL-1, IL-18, and TNF) were all reversed by BMSC-derived exosomes, according to another study (277)

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