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Trans-melanosomal transportation can be achieved through a membrane channel or diffusion, both of which seem to be lacking for GSH, a fact well established in previous research [20,21]

HIV-infected adults in one study were given 300 mg of alpha-lipoic acid three times daily for six months, which resulted in significant elevations in total glutathione [58]

These products are cleaved into glutamine, cysteine, and glycine under the action of 5-oxoalaninase and Cys-Gly peptidase, respectively, and then added to new GSH synthesis [32, 37] (summarized in Fig