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Individuals taking other diabetes medications, particularly other GLP-1 agonists or insulin, should discuss combination therapy carefully with their healthcare provider before starting semaglutide

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Its primary mechanisms include upregulation of vascular endothelial growth factor (VEGF) receptor expression, promotion of angiogenesis, and interaction with the nitric oxide system

doi: 10.1016/j.eclinm.2021.101019 55 TanaCBentivegnaEChoSJHarriottAMGarca-AzornDLabastida-RamirezAet al

For combination protocols, published curves show the cagrilintide-plus-semaglutide arm pulling ahead of either single agent during this period (Frias et al., 2023)