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Colonic melanosis was first reported in literature about 140 years ago by Cruveilhier, who described it in a patient with chronic diarrhea in which "the inner surface of the large intestine was black as" China ink "
R., Telarico, T., Bonilla, E., Li, Q., Banerjee, S., Middleton, F
The first approach built from the core 34 residue PYY(336), attempting to incorporate key exendin-4 residues in a hybridization approach
A 2013 Cochrane review performed on 52,044 randomized participants showed limited positive effects of the MedDiet on cardiovascular risk (66), whereas in the same year a meta-analysis performed on 3,073 randomly assigned individuals with different dietary regimes showed that the MedDiet as well as diets characterized by low-glycemic index, low-carbohydrate and high-protein determined an improvement in cardiovascular risk factors in patients with diabetes (67)
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